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Australian Journal of Pharmacy : August 2005
GET ON TOP STAY ON TOP † † Avandia can help your patients control their diabetes.1,2 Initiate Avandia early It provides long-term glycaemic control and improved beta-cell function.*1-11 and help your patients get on top and stay on top of diabetes.1-5 U AVANDIA NOW PBS LISTED *Compared to baseline Please review Product Information before prescribing. References: 1. Avandia Product Information. 2. Dailey GE et al. Am J Med 2004; 116: 223-229. 3. Jones TA et al. Diab Obes & Metab 2003;5:163-170. 4. Gould E & Cobitz A. Poster Presentation, 84th Annual Meeting of the Endocrine Society 2002, San Francisco, USA: 1-60. 5. Rosenstock J et al. Diabetes Metab 2003; 29 (Suppl.2): 4S247-4S248 (Abs No. 2278). 6. Matthews DR et al Diabetologia 1999; 42: A228 abs 858 & poster. 7. Matthews DR. Diab Obes & Metab 2001; 3(Suppl.1):S28-S33. 8. Reusch JEB et al. Diab Tech & Ther 2003; 5(4): 685-693. 9. Wolffenbuttel BHR et al. Diab Med 2000; 17: 40-47. 10. Fonseca V et al. JAMA 2000; 283: 1695-1702. 11. Lebovitz HE. J Clin & Metab 2001; 86:280-288. AVANDIA. (rosiglitazone maleate) Indications: Treatment of Type 2 diabetes mellitus. In patients inadequately controlled by diet and exercise, as monotherapy, in dual combination therapy with sulphonylureas, metformin or insulin and in triple combination therapy with metformin and sulphonylureas. Dosage: Initiated at 4mg/day. Can be increased to 8mg/day after 6-8 weeks if greater glycaemic control is required. May be given once or twice daily. Contraindications: Hypersensitivity. Precautions: Type 1 diabetes mellitus; Premenopausal anovulatory patients with insulin resistance (eg. polycystic ovary syndrome); New York Heart Association (NYHA) classified heart failure; hepatic dysfunction/impairment; Pregnancy (Category B3); Lactation; Children. Interactions: Drug interactions with gemfibrozil and rifampicin have been reported. Side Effects: Headache, back pain, hyperglycaemia, fatigue, diarrhoea, hypoglycaemia, oedema, anaemia, weight gain, hepatic dysfunction. (This is not a full list, refer to full PI for details). PBS dispensed price (Authority required): Avandia 4mg $61.65 for 28 tablets (4 or 5 rpts); Avandia 8mg $92.29 for 28 tablets (4 or 5 rpts). Full disclosure Product Information is available from GlaxoSmithKline Australia Pty. Ltd. Further information is available upon request from the Medical Information Department GlaxoSmithKline Australia Pty Ltd. on 1800 033 109. ABN 47 100 162 481, 1061 Mountain Hwy, Boronia, Vic 3155. Avandia® is a registered trade mark of the GlaxoSmithKline Group of Companies. PC050741 PBS Information: Authority Required. Refer to PBS Schedule for full Authority Required information for use of Avandia in dual or triple therapy. I N S L I N T M E L T O R T I S M R U L A E U + P S D U E