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Australian Journal of Pharmacy : November 2006
POWER OF DUAL INHIBITION. 1,2 ADD EZETROL SUBTRACT LDL. ® 1,2 Add EZETROL to a statin to achieve powerful cholesterol reduction1 PBS Information: Authority Required. Initial treatment for co-administration with statin =40mg/day in patients with CHD, symptomatic CVD, PVD, familial hypercholesterolaemia or diabetes mellitus whose cholesterol levels are inadequately controlled after =3 months treatment with =40mg statin. As monotherapy in patients intolerant to statins or where statins are contraindicated. Refer to PBS Schedule for full authority requirement information. PLEASE REVIEW APPROVED PRODUCT INFORMATION BEFORE PRESCRIBING. FULL PRODUCT INFORMATION IS AVAILABLE FROM MERCK SHARP & DOHME. Use: Adjunct to diet in treatment of primary hypercholesterolaemia (+/-statin); homozygous familial hypercholesterolaemia (+statin); homozygous sitosterolaemia (phytosterolaemia). Contra: Hypersensitivity to any component of the product. All of the following when used in combination with a statin: active liver disease, unexplained persistent serum transaminase elevations, pregnancy (Category B3), lactation. Prec: Unexplained muscle pain; moderate to severe hepatic insufficiency; monitor LFTs (+statin); fibrates (coadmin not recommended); monitor INR with warfarin; monitor cyclosporin concentrations; pregnancy, lactation, children <10 years. Adverse: hypersensitivity reactions; anaphylaxis, myalgia, myopathy/rhabdomyolysis (with statin); incr CPK; elev liver transaminases; cholelithiasis, cholecystitis; hepatitis; thrombocytopenia; pancreatitis; nausea; others, see full PI. Interact: Cholestyramine; fibrates (coadmin not recommended, see full PI). Tablet: Rx (S4) Ezetimibe; lactose; white/off-white. Pack: 10mg  Dose 10mg once daily; Authority – used alone or with a statin. PBS Price: $69.70. References: 1. Approved Product Information for EZETROL. 2. Gagn´e C, et al. Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. Am J Cardiol, 2002; 90: 1084–91. ® trademark of MSP Singapore Company, LLC. Merck Sharp & Dohme (Australia) Pty Limited 54-68 Ferndell Street South Granville NSW 2142. H&T MSD0550/AJP. 09-07-EZT-06-MSP-1450-J EZETROL is a registered 11 Gibbon Road, Baulkham Hills NSW 2153, Australia